Shire plc

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Shire and SAIIDAC announce planned delisting of notes from the New York Stock Exchange Dublin, Ireland – January 11, 2019 – Shire plc (“Shire”) and Shire Acquisitions Investments Ireland DAC, an Irish designated activity company and wholly-owned subsidiary of...... 13:00 GMT Friday 11th January 2019

De-listing and cancellation of trading of Shire Shares Further to the announcement made by Shire plc (“”) on January 8, 2019, Shire today announces that, following an application by Shire, the UK Listing Authority has cancelled the...... 03:09 GMT Wednesday 9th January 2019

Director/PDMR Shareholding Shire is now part of Takeda....... 12:30 GMT Tuesday 8th January 2019

Scheme becomes effective On May 8, 2018, Shire plc (“”) and Takeda Pharmaceutical Company Limited (“”) announced that they had reached agreement on the terms of a recommended cash and share offer t...... 02:00 GMT Tuesday 8th January 2019

Scheme becomes effective On May 8, 2018, Shire plc (“”) and Takeda Pharmaceutical Company Limited (“”) announced that they had reached agreement on the terms of a recommended cash and share offer t...... 19:09 GMT Monday 7th January 2019

Holding(s) in Company Shire is the global biotechnology leader serving patients with rare diseases and specialized conditions. We seek to push boundaries through discovering and delivering new possibili...... 12:00 GMT Monday 7th January 2019

Court sanction of the Scheme Shire plc (“”) is pleased to announce that the Royal Court of Jersey has today sanctioned the scheme of arrangement pursuant to Article 125 of the Companies (Jersey) Law 1991 (...... 07:15 GMT Thursday 3rd January 2019

Holding(s) in Company Shire is the global biotechnology leader serving patients with rare diseases and specialized conditions. We seek to push boundaries through discovering and delivering new possibili...... 10:15 GMT Wednesday 2nd January 2019

Total voting rights As at December 31, 2018, the Company’s issued ordinary share capital comprised 925,477,681 ordinary shares of 5 pence each with voting rights and a further 7,357,283 ordinary sha...... 05:30 GMT Wednesday 2nd January 2019

Rule 2.9 Announcement In accordance with Rule 2.9 of the City Code on Takeovers and Mergers, the Company confirms that, as at the close of business on 28 December 2018, being the last business day prior...... 02:00 GMT Monday 31st December 2018

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