New Preclinical Studies Reinforce the Potential for Heightened Anti-Cancer Activity of Combination Therapies Based on Immunovaccine’s Proprietary Delivery Platform

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HALIFAX, Nova Scotia, April 16, 2018 (GLOBE NEWSWIRE) -- Immunovaccine Inc. (TSX:IMV) (OTCQX:IMMVF), a clinical stage immuno-oncology company, today announced that it presented new research on its T-cell activating platform at the .

In collaboration with Incyte Corporation, researchers presented a poster supporting the enhanced anti-cancer immune responses from the combination of Immunovaccine’s proprietary T cell activating technology and Incyte’s IDO1 inhibitor program. A second poster analyzed the novel capability, as compared to other formulation technologies, of Immunovaccine’s delivery technology to combine a large range of anti-cancer peptides into a single formulation.

“This is important data for our Company as it further indicates the potential of our collaborative work, including our ongoing program with Incyte, to provide heightened T cell infiltration and overall anti-cancer immune responses,” said . “Our data at AACR continues to demonstrate that our novel mechanism of action may hold the key to bridging the gap between therapies that can elicit T cell activation, and immune responses that can trigger disease regression. We look forward to continued work on these important programs.”

In the poster, “Combination of a T cell activating immunotherapy with immune modulators alters the tumour microenvironment and promotes more effective tumour control in preclinical models,” researchers presented new preclinical analysis on the combination of Immunovaccine’s DPX-based therapies, Incyte’s epacadostat, and low-dose cyclophosphamide in tumor models. As part of the analysis, researchers also examined the potential for heightened tumor response from T cell infiltration in the tumour microenvironment. The study indicated that the triple combination immunotherapy demonstrated a significant delay in tumour progression. Analysis of the T cells suggested that other immune modulating therapies, such as checkpoint inhibitors, could further enhance tumour control.

Related to Immunovaccine’s neoepitope program, researchers presented the poster, “A novel delivery platform containing up to 25 neoantigens can induce robust immune responses in a single formulation.” This study investigated the effects on immune response when formulating a broad range of peptides across multiple delivery technologies, including the Company’s proprietary formulation. The study indicated that Immunovaccine’s novel technology could incorporate at least 25 neo-antigens into a single formulation, which generated strong CD8+ T cell responses, in excess of those induced by other formulations.

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Globe Newswire: 14:05 GMT Monday 16th April 2018

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