World News: 05:00 GMT Friday 9th November 2018. [Aptevo Therapeutics Inc. via Globe Newswire via SPi World News]
LUND, Sweden and SEATTLE, Nov. 08, 2018 (GLOBE NEWSWIRE) -- Alligator Bioscience (Nasdaq Stockholm: ATORX), a biotechnology company developing antibody-based pharmaceuticals for tumor-directed immunotherapy, and Aptevo Therapeutics Inc. (Nasdaq: APVO), a biotechnology company focused on developing novel immuno-oncology and hematology therapeutics, today announced that new preclinical data for ALG.APV-527 are being presented at the Society for Immunotherapy of Cancer's (SITC) 33rd Annual Meeting being held in Washington, D.C., November 9-11, 2018.
ALG.APV-527 is a new immunotherapeutic candidate for the treatment of a variety of 5T4-positive solid tumors. It is designed to induce signaling through the co-stimulatory receptor 4-1BB (CD137), which is present on activated cytotoxic T cells and natural killer (NK) cells. Once activated, it is designed to promote potent and selective tumor-directed immune activation in the presence of 5T4 antigen-expressing tumor cells, which are present on many different types of solid tumors.
The preclinical data show that ALG.APV-527 localizes to 5T4 positive tumors and selectively stimulates and enhances tumor-directed T-cell and NK cell responses, displaying potent anti-tumor effects. Notably, the preclinical data demonstrated that in the presence of 5T4-positive cells, ALG.APV-527:
Additionally, these new data confirm that 5T4 antigen is present on a wide range of tumor types. 5T4-positive tumor cells were detected in tumor samples from NSCLC (non-small cell lung cancer), head and neck, mesothelioma-, pancreatic-, bladder-, renal- and ovarian cancer, but not in normal tissues such as liver or heart.
“The latest preclinical data further strengthen ALG.APV-527’s potential to localize to 5T4-expressing tumors, where it selectively can activate the immune system and enhance tumor specific T cell or NK activation at the tumor site, potentially providing a favorable safety profile while enhancing efficacy. We are currently compiling a preclinical package with the goal of submitting a clinical trial application (CTA) in late 2019,” said Christina Furebring Ph.D., Senior Vice President Research at Alligator.
“Our novel bispecific candidate, ALG.APV-527, continues to show promising results in preclinical and studies. Featuring target-driven T-cell activation, optimized stability, an antibody-like serum half-life of 9 days, and good manufacturing properties. Aptevo and Alligator believe that ALG.APV-527 has the potential to be a unique anti-cancer therapeutic for the treatment of numerous 5T4-expressing solid tumors with high unmet medical need. We look forward to filing the CTA next year and commencing clinical study of this promising immunotherapy,” said Jane Gross, Ph.D., Chief Scientific Officer for Aptevo.
The Alligator/Aptevo poster presentation, entitled is being presented November 9, 2018 from 12:45pm – 2:45 pm and 6:30 pm – 8:30 pm ET.
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There are a number of important factors that could cause Aptevo’s actual results to differ materially from those indicated by such forward-looking statements, including a deterioration in Aptevo’s business or prospects; adverse developments in research and development; adverse developments in the U.S. or global capital markets, credit markets or economies generally; and changes in regulatory, social and political conditions. Additional risks and factors that may affect results are set forth in Aptevo’s filings with the Securities and Exchange Commission, including its most recent Annual Report on Form 10-K, as filed on March 13, 2018, as amended, and its subsequent reports on Form 10-Q and current reports on Form 8-K. The foregoing sets forth many, but not all, of the factors that could cause actual results to differ from Aptevo’s expectations in any forward-looking statement.
Globe Newswire: 05:00 GMT Friday 9th November 2018
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