VALNEVA and HOOKIPA Sign a Collaboration and Manufacturing Agreement

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Under the terms of the agreement, Valneva Sweden will provide analytical services, develop process scale-up and produce GMP clinical trial material to support the development of new immunotherapies based on HOOKIPA's Vaxwaveand TheraTarenavirus vector- technologies. In return, Valneva will receive fixed and success-based service fees. The agreement may be extended beyond three years.

Our proprietary arenavirus-based technologies, Vaxwave, a replication-deficient viral vector, and TheraT, a replication-attenuated viral vector, are designed to induce robust antigen specific CD8+ T cells and pathogen-neutralizing antibodies. Both, Vaxwave and TheraT, are designed to allow for repeat administration while maintaining an immune response. TheraT has the potential to induce CD8+ T cell response levels previously not achieved by other published immuno-therapy approaches. Our "off-the-shelf" viral vectors target dendritic cells to activate the immune system.

We have successfully completed a Phase 1 trial of a Vaxwave-based prophylactic vaccine to protect against cytomegalovirus infection. We have initiated enrollment for a Phase 2 trial in cytomegalovirus-negative patients awaiting kidney transplantation from cytomegalovirus-positive donors. To expand our infectious disease portfolio, we have entered into a collaboration and licensing agreement with Gilead Sciences, Inc. to jointly research and develop functional cures for HIV and Hepatitis B infections. We are building a proprietary immuno-oncology pipeline by targeting virally mediated cancer antigens, self-antigens and next-generation antigens. 

Find out more about HOOKIPA online at .

*Registered in Europe; Pending in the US.

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Globe Newswire: 16:46 GMT Thursday 6th December 2018

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