World News: 07:00 GMT Tuesday 14th January 2020. [OSE Immunotherapeutics via Globe Newswire via SPi World News]
NANTES, France, Jan. 14, 2020 (GLOBE NEWSWIRE) -- (ISIN: FR0012127173; Mnémo: OSE) today announced that the Japanese Patent Office has issued a new patent family related to Tedopi, a combination of neoepitopes, protecting the product’s method for inducing early T-lymphocyte memory response for use in the treatment of cancer in HLA-A2 positive patients. This patent provides a protection until 2035.
Tedopi is a combination of 10 neo-epitopes, selected and optimized from five tumor-associated antigens inducing a specific immune response in positive HLA-A2 patients. In association with T helper cells, the memory T lymphocytes recognize specifically at least one of these tumor-associated antigens expressed by the tumor cells and generate a specific cytotoxic response against them.
Due to this specific mechanism of action, activated specific T memory lymphocytes are key cells in cancer treatment and immunosurveillance.
Tedopi is currently being evaluated in a Phase 3 trial, called , in advanced non-small cell lung cancer (NSCLC) for HLA-A2 positive patients after failure from previous treatment with PD-1/PD-L1 checkpoint inhibitors. Even with recent advances in treatment options, the majority of NSCLC patients still fail to respond to checkpoint inhibitor therapy**, creating a great need for an effective new option for these patients. Results from the first step of this ongoing Phase 3 trial are expected by the end of Q1 2020. Tedopi is also being studied in an ongoing Phase 2 trial in patients with pancreatic cancer.
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Globe Newswire: 07:00 GMT Tuesday 14th January 2020
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